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Soohong Kim, Anna Gottfried, Ron R. Lin, Dr. Thomas Dertinger, Andrew S. Kim, Sangyoon Chung, Dr. Ryan A. Colyer, Prof. Dr. Elmar Weinhold, Prof. Shimon Weiss and Dr. Yuval Ebenstein Enzymatically Incorporated Genomic Tags for Optical Mapping of DNA-Binding Proteins Angewandte Chemie International Edition 51

Version of Record online: 16 FEB 2012 | DOI: 10.1002/anie.201107714

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All smiles: Sequence-specific methyltransferase-induced labeling of DNA (SMILing DNA) creates a fluorescence pattern of the T7 bacteriophage genome (see picture). The pattern is visualized as a linear optical barcode showing the genomic location of individual RNA polymerases bound to the DNA. The precision of the measurement presents new opportunities for contextual genomic research on the single-molecule level.

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