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Dr. Keiichi Yoshimatsu, Benjamin K. Lesel, Dr. Yusuke Yonamine, Dr. John M. Beierle, Dr. Yu Hoshino and Prof. Kenneth J. Shea Temperature-Responsive “Catch and Release” of Proteins by using Multifunctional Polymer-Based Nanoparticles Angewandte Chemie International Edition 51

Version of Record online: 27 JAN 2012 | DOI: 10.1002/anie.201107797

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Catch me if you can: Multifunctional, polymer-based nanoparticles that are capable of temperature-responsive “catch-and-release” of a target protein have been synthesized. The process is reversible and does not denature the proteins. An optimized combination of functional monomers imparts binding selectivity toward a target protein over other proteins.

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