Dr. Cheng Wang, Zongxi Li, Dennis Cao, Dr. Yan-Li Zhao, Justin W. Gaines, Dr. O. Altan Bozdemir, Michael W. Ambrogio, Dr. Marco Frasconi, Dr. Youssry Y. Botros, Prof. Jeffrey I. Zink and Prof. J. Fraser Stoddart Stimulated Release of Size-Selected Cargos in Succession from Mesoporous Silica Nanoparticles Angewandte Chemie International Edition 51
Version of Record online: 13 APR 2012 | DOI: 10.1002/anie.201107960
Two birds with one stone: Covalent attachment of β-cyclodextrin rings (yellow; see figure) to mesoporous silica nanoparticles (MSNs) results in a dual-cargo release system into which differently sized cargos (blue and red spheres) can be loaded and then released in sequence when triggered by two different stimuli. The smaller molecules are released by lowering the pH value and the larger ones released after cleavage of the cyclodextrins from the MSN surface.
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