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Chayasith Uttamapinant, Anupong Tangpeerachaikul, Dr. Scott Grecian, Dr. Scott Clarke, Dr. Upinder Singh, Dr. Peter Slade, Dr. Kyle R. Gee and Prof. Alice Y. Ting Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling Angewandte Chemie International Edition 51

Article first published online: 3 MAY 2012 | DOI: 10.1002/anie.201108181

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Bring your own copper: Copper-chelating azides undergo much faster click reactions (CuAAC) than nonchelating azides under a variety of biocompatible conditions. This kinetic enhancement allows site-specific protein labeling to be performed on the surface of living cells with only 10–40 μM CuI/CuII (see scheme). Detection sensitivity was also increased for CuAAC detection of alkyne-modified proteins and RNA.

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