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Dipl.-Biochem. Swantje Behnken, Dr. Thorger Lincke, Dipl.-Chem. Florian Kloss, Dr. Keishi Ishida and Prof. Dr. Christian Hertweck Antiterminator-Mediated Unveiling of Cryptic Polythioamides in an Anaerobic Bacterium Angewandte Chemie International Edition 51

Version of Record online: 27 JAN 2012 | DOI: 10.1002/anie.201108214

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Anti-Terminator: Rise of the Molecules: Overexpression of an antiterminator gene (nusG) in Clostridium cellulolyticum induced the biosynthesis of the novel antibiotic closthioamide and related thioamides. This is the first successful genetic engineering of an anaerobe to trigger a cryptic pathway. Furthermore, synthetic probes provide valuable insights into the biogenetic relationship of the rare thioamide metabolites.

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