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Dr. Filip Bihelovic and Prof. Dr. Radomir N. Saicic Total Synthesis of (−)-atrop-Abyssomicin C Angewandte Chemie International Edition 51

Version of Record online: 23 APR 2012 | DOI: 10.1002/anie.201108223

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Rolling in the deep: An enantioselective synthesis of a marine antibiotic (−)-atrop-abyssomicin C (see scheme) is described. The key steps of the synthetic sequence are the application of dual catalysis in the formation of the cyclohexane core, the gold-catalyzed formation of a tricyclic spirotetronate unit, and a highly efficient eleven-membered ring closure by a Nozaki–Hiyama–Kishi reaction.

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