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Susan Strom, Udayanga Wanninayake, Nishanka Dilini Ratnayake, Prof. Kevin D. Walker and Prof. James H. Geiger Insights into the Mechanistic Pathway of the Pantoea agglomerans Phenylalanine Aminomutase Angewandte Chemie International Edition 51

Version of Record online: 8 FEB 2012 | DOI: 10.1002/anie.201108525

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The structure of the title aminomutase has been solved. The steric bulk of Phe 455 (green CPK structure) twists the phenylpropanoate ligand (green stick) by approximately 15° about the Cβ axis, which precludes a stronger bidentate salt bridge with Arg 323 (magenta structure). Instead, a weaker monodentate bridge may partially explain the different configuration of the product, relative to that obtained with an isoenzyme that forms a bidentate intermediate.

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