Kyungtae Kang, Sung-Eun Choi, Hee Su Jang, Dr. Woo Kyung Cho, Prof. Dr. Yoonkey Nam, Prof. Dr. Insung S. Choi and Prof. Dr. Jin Seok Lee Cover Picture: In Vitro Developmental Acceleration of Hippocampal Neurons on Nanostructures of Self-Assembled Silica Beads in Filopodium-Size Ranges (Angew. Chem. Int. Ed. 12/2012) Angewandte Chemie International Edition 51
Topographical cues play an important role in in vitro neuronal development. In their Communication on page 2855 ff., Y. Nam, I. S. Choi, J. S. Lee, and co-workers show that neuritogenetic acceleration occurs on silica-bead monolayers made up of beads with a diameter of more than 200 nm, but not on monolayers of beads with smaller diameters. The biochemical study indicates neurons sense topographical differences in nanostructures and alter their behavior accordingly.
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