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Sebastian Blanck, Dr. Jasna Maksimoska, Julia Baumeister, Dr. Klaus Harms, Prof. Ronen Marmorstein and Prof. Dr. Eric Meggers The Art of Filling Protein Pockets Efficiently with Octahedral Metal Complexes Angewandte Chemie International Edition 51

Article first published online: 1 MAR 2012 | DOI: 10.1002/anie.201108865

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Better fit, less effort: An easy-to-synthesize ruthenium phthalimide complex (tan-colored carbon atoms in the picture) was designed to bind within the active site of the p21-activated kinase 1 in a novel fashion that differs from that of the previously established staurosporine-inspired metallopyridocarbazoles (gray-colored carbon atoms).

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