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Dr. Linlin Zhao, Dr. Plamen P. Christov, Dr. Ivan D. Kozekov, Dr. Matthew G. Pence, Dr. Pradeep S. Pallan, Prof. Dr. Carmelo J. Rizzo, Prof. Dr. Martin Egli and Prof. Dr. F. Peter Guengerich Replication of N2,3-Ethenoguanine by DNA Polymerases Angewandte Chemie International Edition 51

Version of Record online: 4 APR 2012 | DOI: 10.1002/anie.201109004

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Damaged goods: The unstable DNA adduct N2,3-ethenoguanine, a product of both exposure to the carcinogen vinyl chloride and of oxidative stress, was built into an oligonucleotide, using an isostere strategy to stabilize the glycosidic bond. This modification was then used to examine the cause of mutations by DNA polymerases, in terms of both the biochemistry of the lesion and a structure of the lesion within a polymerase (see scheme).

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