Prof. Dr. Francisco J. Fañanás, Dr. Abraham Mendoza, Tamara Arto, Dr. Baris Temelli and Prof. Félix Rodríguez Scalable Total Synthesis of (−)-Berkelic Acid by Using a Protecting-Group-Free Strategy Angewandte Chemie International Edition 51
Supply chain: The polycyclic core of (−)-berkelic acid (1) was constructed in just one step from very simple starting materials. The total synthesis of 1 involves a seven-step linear sequence. Protection/deprotection steps were avoided and all but the last step were performed on a gram scale. This synthesis could solve the supply problem associated with the exhaustion of the natural source.
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