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Dr. Yuanpei Li, Dr. Wenwu Xiao, Dr. Kai Xiao, Dr. Lorenzo Berti, Prof. Juntao Luo, Harry P. Tseng, Gabriel Fung and Prof. Kit S. Lam Inside Back Cover: Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis-Diols (Angew. Chem. Int. Ed. 12/2012) Angewandte Chemie International Edition 51

Version of Record online: 20 JAN 2012 | DOI: 10.1002/anie.201109103

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A cross-linked micellar nanocarrier system for on-demand drug delivery is described by J. Luo, K. S. Lam, and co-workers in their Communication on page 2864 ff. The reversible catechol boronate cross-link increases the stability of the nanocarriers against severe conditions in the blood stream. After the ball-like nanocarriers reach the tumor target, the cross-links are cleaved by the acidic tumor environment or by exogenous cis-diols (e.g. mannitol), causing the ball to burst and releasing the drug.

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