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Linjie Han, Dr. Suk-Joon Hyung and Prof. Brandon T. Ruotolo Bound Cations Significantly Stabilize the Structure of Multiprotein Complexes in the Gas Phase Angewandte Chemie International Edition 51

Article first published online: 23 APR 2012 | DOI: 10.1002/anie.201109127

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Positively a gas: Protein structure determination using mass spectrometry can be assisted by the addition of stabilizing cations to the gas-phase molecule. Densely charged cations (see scheme, green) are found to stabilize protein tertiary structure for accurate mass determination of homo- or heterogeneous protein complexes. The cations remain tightly bound to the protein throughout the analysis, allowing the protein to remain in a folded state.

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