Linjie Han, Dr. Suk-Joon Hyung and Prof. Brandon T. Ruotolo Bound Cations Significantly Stabilize the Structure of Multiprotein Complexes in the Gas Phase Angewandte Chemie International Edition 51
Positively a gas: Protein structure determination using mass spectrometry can be assisted by the addition of stabilizing cations to the gas-phase molecule. Densely charged cations (see scheme, green) are found to stabilize protein tertiary structure for accurate mass determination of homo- or heterogeneous protein complexes. The cations remain tightly bound to the protein throughout the analysis, allowing the protein to remain in a folded state.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf