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Dr. Norman Metanis and Prof. Dr. Donald Hilvert Strategic Use of Non-Native Diselenide Bridges to Steer Oxidative Protein Folding Angewandte Chemie International Edition 51

Version of Record online: 27 MAR 2012 | DOI: 10.1002/anie.201109129

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Targeted insertion of a non-native diselenide cross-link into a cysteine-rich protein can be exploited to direct the early stages of oxidative folding so as to avoid accumulation of unproductive intermediates that limit folding efficiency. This simple strategy could facilitate the production of many difficult-to-fold peptides and proteins.

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