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Koji Chiyoda, Dr. Jun Shimokawa and Prof. Dr. Tohru Fukuyama Total Syntheses of All the Amathaspiramides Angewandte Chemie International Edition 51

Version of Record online: 27 JAN 2012 | DOI: 10.1002/anie.201109221

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Six in one blow: Total syntheses of all the amathaspiramide alkaloids have been accomplished. Rapid construction of the diazaspiro[3.3]nonane core combined with regio- and diastereoselective reduction of the cyclic imide moiety with DIBAL established the route to the common structural motif. The late-stage reduction of the lactam to an imine functionality mediated by Schwartz's reagent was the key to the streamlined syntheses.

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