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Dr. Sreekumar Pankajakshan, Dr. Yun-He Xu, Jun Kee Cheng, Man Ting Low and Prof. Dr. Teck-Peng Loh Palladium-Catalyzed Direct C[BOND]H Arylation of Enamides with Simple Arenes Angewandte Chemie International Edition 51

Article first published online: 19 APR 2012 | DOI: 10.1002/anie.201109247

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Z only: An atom-economical synthetic route towards arylated Z-enamides through double C[BOND]H functionalization is described. The Z/E selectivity of the palladium-catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential second arylation, which requires the use of trifluoracetic acid (TFA; step B).

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