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Dipl.-Chem. Philipp Stawski, Dr. Martin Sumser and Prof. Dr. Dirk Trauner A Photochromic Agonist of AMPA Receptors Angewandte Chemie International Edition 51

Version of Record online: 19 APR 2012 | DOI: 10.1002/anie.201109265

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Light switch: A photochromic agonist ATA-3 (see scheme) of AMPA receptors, arguably the most important class of ionotropic glutamate receptors, is shown to be subtype selective, activates the AMPA receptor GluA2 in the dark, and is quickly turned off when irradiated with blue–green light. It can be used to effectively control neuronal activity in the mammalian brain.

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