Linglin Wu, Laura Falivene, Dr. Emma Drinkel, Sharday Grant, Priv.-Doz. Dr. Anthony Linden, Prof. Dr. Luigi Cavallo and Prof. Dr. Reto Dorta Synthesis of 3-Fluoro-3-aryl Oxindoles: Direct Enantioselective α Arylation of Amides Angewandte Chemie International Edition 51
Modus operandi: Catalytic access to the title compounds through a new asymmetric α-arylation protocol is reported (see scheme). These products are formed in good yields and excellent enantioselectivities by using a new and easily synthesized chiral N-heterocyclic carbene (NHC) ligand. Advanced DFT calculations reveal the properties of the NHC ligand and the mode of operation of the catalyst.
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