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Christine Jahns, Thomas Hoffmann, Stefan Müller, Dr. Klaus Gerth, Dr. Peter Washausen, Prof. Dr. Gerhard Höfle, Prof. Dr. Hans Reichenbach, Prof. Dr. Markus Kalesse and Prof. Dr. Rolf Müller Pellasoren: Structure Elucidation, Biosynthesis, and Total Synthesis of a Cytotoxic Secondary Metabolite from Sorangium cellulosum Angewandte Chemie International Edition 51

Article first published online: 5 APR 2012 | DOI: 10.1002/anie.201200327

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Genetic analysis of biosynthetic gene clusters is becoming an accepted tool to predict the stereochemical outcome of a biosynthesis. However, in the case of pellasoren, one chiral center was not predicted correctly. The absolute configuration was verified by total synthesis, which also demonstrated that stereoselective protonations can be successfully applied to natural products synthesis.

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