E-mail a Wiley Online Library Link

Christine Jahns, Thomas Hoffmann, Stefan Müller, Dr. Klaus Gerth, Dr. Peter Washausen, Prof. Dr. Gerhard Höfle, Prof. Dr. Hans Reichenbach, Prof. Dr. Markus Kalesse and Prof. Dr. Rolf Müller Pellasoren: Structure Elucidation, Biosynthesis, and Total Synthesis of a Cytotoxic Secondary Metabolite from Sorangium cellulosum Angewandte Chemie International Edition 51

Version of Record online: 5 APR 2012 | DOI: 10.1002/anie.201200327

Thumbnail image of graphical abstract

Genetic analysis of biosynthetic gene clusters is becoming an accepted tool to predict the stereochemical outcome of a biosynthesis. However, in the case of pellasoren, one chiral center was not predicted correctly. The absolute configuration was verified by total synthesis, which also demonstrated that stereoselective protonations can be successfully applied to natural products synthesis.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field