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Dr. Angel Tan, Amanda Martin, Dr. Tri-Hung Nguyen, Prof. Ben J. Boyd and Prof. Clive A. Prestidge Hybrid Nanomaterials that Mimic the Food Effect: Controlling Enzymatic Digestion for Enhanced Oral Drug Absorption Angewandte Chemie International Edition 51

Version of Record online: 13 APR 2012 | DOI: 10.1002/anie.201200409

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Easily digested: SiO2–lipid hybrid microparticles with specific nanostructured interiors were generated from submicrometer-sized emulsion templates based on mesoporous and non-porous silica nanoparticles. These functional lipid-based microparticles can be used to mimic the pharmaceutical food effect and enhance drug absorption by controlling the enzymatic digestion of lipid colloids (see scheme; ○ oil solution, ▴ lipid–nanoparticle hybrid, □ lipid encapsulated in hybrid).

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