Dr. Corwin M. Nycholat, Ryan McBride, Dr. Damian C. Ekiert, Dr. Rui Xu, Janani Rangarajan, Dr. Wenjie Peng, Dr. Nahid Razi, Dr. Michel Gilbert, Dr. Warren Wakarchuk, Prof. Ian A. Wilson and Prof. James C. Paulson Recognition of Sialylated Poly-N-acetyllactosamine Chains on N- and O-Linked Glycans by Human and Avian Influenza A Virus Hemagglutinins Angewandte Chemie International Edition 51
Version of Record online: 13 APR 2012 | DOI: 10.1002/anie.201200596
Human influenza viruses are proposed to recognize sialic acids (pink diamonds) on glycans extended with poly-LacNAc chains (LacNAc=(yellow circle+blue square)). N- and O-linked glycans were extended with different poly-LacNAc chains with α2-3- and α2-6-linked sialic acids recognized by human and avian influenza viruses, respectively. The specificity of recombinant hemagglutinins (receptors in green) was investigated by using glycan microarray technology.
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