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Prof. Barry M. Trost, Max M. Hansmann and David A. Thaisrivongs Palladium-Catalyzed Alkylation of 1,4-Dienes by C[BOND]H Activation Angewandte Chemie International Edition 51

Version of Record online: 4 APR 2012 | DOI: 10.1002/anie.201200601

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Activated: The title reaction proceeds with a broad range of nucleophiles and variously substituted 1,4-dienes under mild conditions, and provides direct access to the corresponding 1,3-diene-containing products with high regio- and stereocontrol (see scheme; 2,6-DMBQ=2,6-dimethylbenzoquinone, EWG=electron-withdrawing group). This is the first catalytic allylic C[BOND]H alkylation that proceeds in the absence of sulfoxide ligands.

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