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Ly Dieu Tran and Prof. Dr. Olafs Daugulis Nonnatural Amino Acid Synthesis by Using Carbon–Hydrogen Bond Functionalization Methodology Angewandte Chemie International Edition 51

Version of Record online: 12 APR 2012 | DOI: 10.1002/anie.201200731

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Taking direction well: Substituted phenylalanine derivatives were prepared by C[BOND]H bond functionalization (see scheme). The syntheses are highly convergent and employ an N-phthaloylalanine with a 2-thiomethylaniline directing group. The use of an 8-aminoquinoline directing group allows for the diarylation of methyl and the diastereoselective arylation of methylene groups.

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