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Mitchell R. O'Connell, Dr. Marylène Vandevenne, Cuong D. Nguyen, Prof. Jacqueline M. Matthews, Dr. Roland Gamsjaeger, Prof. David J. Segal and Prof. Joel P. Mackay Modular Assembly of RanBP2-Type Zinc Finger Domains to Target Single-Stranded RNA Angewandte Chemie International Edition 51

Article first published online: 19 APR 2012 | DOI: 10.1002/anie.201200866

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Fingering RNA: To study the function of the variety of RNA species that have been discovered recently, sequence-specific RNA-binding molecules with tunable specificity are required. Here, the use of zinc fingers (ZFs) from the splicing factors ZRANB2 and RBM5 as potential modules for the assembly of sequence-specific RNA-binding molecules is demonstrated.

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