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Jonathan R. McDaniel, Dr. Jayanta Bhattacharyya, Kevin B. Vargo, Wafa Hassouneh, Prof. Daniel A. Hammer and Prof. Ashutosh Chilkoti Self-Assembly of Thermally Responsive Nanoparticles of a Genetically Encoded Peptide Polymer by Drug Conjugation Angewandte Chemie International Edition 52

Version of Record online: 20 DEC 2012 | DOI: 10.1002/anie.201200899

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Nanoparticles on demand: Upon the site-specific covalent attachment of hydrophobic molecules to one end of the biopolymer backbone, chimeric polypeptides (derived from elastin-like polypeptides) can self-assemble to form thermoresponsive nanoparticles suitable for drug delivery. Molecules with a distribution coefficient greater than 1.5 imparted sufficient amphiphilicity to drive self-assembly into sub-100 nm nanoparticles (see picture).

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