E-mail a Wiley Online Library Link

Ryuichi Tamura, Yuuya Yamada, Dr. Yoshiaki Nakao and Prof. Dr. Tamejiro Hiyama Alkylation of Pyridone Derivatives By Nickel/Lewis Acid Catalysis Angewandte Chemie International Edition 51

Version of Record online: 19 APR 2012 | DOI: 10.1002/anie.201200922

Thumbnail image of graphical abstract

MAD as an additive: The [Ni(cod)2], (2,6-tBu2-4-MeC6H2O)2AlMe (MAD), and N-heterocyclic carbene (NHC) catalytic system effected a highly regioselective alkylation of pyridone derivatives (see scheme). Substituted pyridones and related heterocycles react with both terminal and internal alkenes to selectively give a range of nitrogen-containing heterocycles with linear alkyl substituents.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field