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Clarence T. T. Wong, Dr. Dewi K. Rowlands, Dr. Chi-Hang Wong, Dr. Theodore W. C. Lo, Giang K. T. Nguyen, Prof. Hoi-Yeung Li and Prof. James P. Tam Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment Angewandte Chemie International Edition 51

Version of Record online: 24 APR 2012 | DOI: 10.1002/anie.201200984

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Edible: By grafting natural peptide antagonists onto the cyclotide kalata B1, orally active peptides were engineered, which are potentially useful therapeutics for the treatment of inflammatory pain. For example, the entire loop 6 of kalata B1 was replaced with the peptidic bradykinin B1 receptor antagonist DALK (red in scheme) to obtain the cyclic bradykinin antagonist ckb-kal.

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