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Dr. Bin Tan, Dr. Gloria Hernández-Torres and Prof. Dr. Carlos F. Barbas III Rationally Designed Amide Donors for Organocatalytic Asymmetric Michael Reactions Angewandte Chemie International Edition 51

Version of Record online: 13 APR 2012 | DOI: 10.1002/anie.201200996

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Amide nucleophiles on demand: Rationally designed pyrazoleamides function as Michael donors in urea-catalyzed asymmetric Michael reactions with excellent chemical and optical yields (see scheme). The pyrazoleamide group performs as an ester equivalent, a directing group, an activating group, and functions as a good leaving group in further transformations of the product.

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