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Dr. Cindy Meyer, Prof. Dr. Winfried Hinrichs and Prof. Dr. Ulrich Hahn Human α2-Macroglobulin—Another Variation on the Venus Flytrap Angewandte Chemie International Edition 51

Version of Record online: 4 APR 2012 | DOI: 10.1002/anie.201201104

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Trapping proteinases: The mechanism of the nonspecific human proteinase inhibitor α2-macroglobulin (α2M, about 6000 amino acid residues) is reminiscent of a Venus flytrap (see scheme). The structure of α2M was solved recently with a resolution of 4.3 Å even though only one single crystal was available.

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