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Dr. Jun Yang, Dr. Mark R. Karver, Weilong Li, Swagat Sahu and Prof. Neal K. Devaraj Metal-Catalyzed One-Pot Synthesis of Tetrazines Directly from Aliphatic Nitriles and Hydrazine Angewandte Chemie International Edition 51

Article first published online: 18 APR 2012 | DOI: 10.1002/anie.201201117

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Paving the way: The lack of convenient synthetic methods is a significant roadblock to the broader use of 1,2,4,5-tetrazines in bioorthogonal chemistry and functional materials. Lewis acid metal catalysts—most notably divalent nickel and zinc salts—are described to catalyze the one-pot synthesis of 1,2,4,5-tetrazines directly from aliphatic nitriles (see scheme).

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