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Harunobu Mitsunuma, Prof. Dr. Masakatsu Shibasaki, Prof. Dr. Motomu Kanai and Dr. Shigeki Matsunaga Catalytic Asymmetric Total Synthesis of Chimonanthine, Folicanthine, and Calycanthine through Double Michael Reaction of Bisoxindole Angewandte Chemie International Edition 51

Article first published online: 12 APR 2012 | DOI: 10.1002/anie.201201132

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Direct access: Sterically hindered vicinal quaternary carbon stereocenters were constructed by catalytic enantio- and diastereoselective double Michael reaction, providing straightforward access to dimeric hexahydropyrroloindole alkaloids. A Mn(4-fluorobenzoate)2/Schiff base complex and a Mg(OAc)2/benzoic acid system were used as catalysts.

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