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Dr. Elena Arceo and Prof. Dr. Paolo Melchiorre Extending the Aminocatalytic HOMO-Raising Activation Strategy: Where Is the Limit? Angewandte Chemie International Edition 51

Version of Record online: 4 APR 2012 | DOI: 10.1002/anie.201201347

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Increasingly remote stereocenters are being targeted in asymmetric aminocatalysis. Application of the HOMO-raising activation concept to δ,δ-disubstituted 2,4-dienones confirms the powerful potential of the trienamine strategy. A cinchona-based primary amine catalyst enables the extension of this activation mode to a highly selective asymmetric Diels–Alder reaction of enones with electron-deficient dienophiles (see scheme; TFA: trifluoroacetic acid).

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