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Dr. Yang Zou and Prof. Dr. Yikang Wu Three Rings in One Step: A Quick Approach to IKD-8344 Angewandte Chemie International Edition 51

Article first published online: 11 APR 2012 | DOI: 10.1002/anie.201201395

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A highly efficient enantioselective total synthesis of the natural antibiotic IKD-8344 is achieved through a convergent route. This route features an otherwise impossible concurrent formation of the THF rings from a linear polyketide precursor through intramolecular O alkylations of mesylates in competition with normally rather facile β elimination and/or α racemization reactions (see scheme, Ms=methanesulfonyl).

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