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Dr. André Horatscheck, M. Sc. Stefan Wagner, Dipl.-Ing. Jutta Ortwein, Dr. Boo Geun Kim, Dr. Michael Lisurek, Dr. Samuel Beligny, Anja Schütz and Prof. Dr. Jörg Rademann Benzoylphosphonate-Based Photoactive Phosphopeptide Mimetics for Modulation of Protein Tyrosine Phosphatases and Highly Specific Labeling of SH2 Domains Angewandte Chemie International Edition 51

Version of Record online: 21 AUG 2012 | DOI: 10.1002/anie.201201475

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A light switch for phosphotyrosine- recognizing proteins: Irradiation of the bioisosteric benzoylphosphonate suffices to “turn off” the activity of target proteins and to label them covalently (see scheme). Photoactive bioisosters may find applications in functional cell biology, bioanalytics, and proteome research.

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