Eunmi Kim, In Taek Song, Slgirim Lee, Jung-Suk Kim, Prof. Haeshin Lee and Prof. Jae-Hyung Jang Drawing Sticky Adeno-Associated Viruses on Surfaces for Spatially Patterned Gene Expression Angewandte Chemie International Edition 51
Sticky stuff: A versatile strategy to spatially control gene expressions of mammalian cells is developed. A catecholamine polymer (PEI-C) is used to functionalize surfaces of adeno-associated viruses (AAV). Because of the underwater adhesive property of catechol, AAV/PEI-C hybrid vectors become highly “sticky”, resulting in spatially patterned viral attachment onto substrates by the simple “gene-vector drawing” technique (see picture).
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