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Dr. Shinobu Takizawa, Tue Minh-Nhat Nguyen, André Grossmann, Prof. Dr. Dieter Enders and Prof. Dr. Hiroaki Sasai Enantioselective Synthesis of α-Alkylidene-γ-Butyrolactones: Intramolecular Rauhut–Currier Reaction Promoted by Acid/Base Organocatalysts Angewandte Chemie International Edition 51

Version of Record online: 18 APR 2012 | DOI: 10.1002/anie.201201542

Thumbnail image of graphical abstract

Teaming up: The title reaction has been developed to deliver the product α-alkylidene-γ-butyrolactones as single diastereomers with up to 98 % ee (see scheme; Ts=4-toluenesulfonyl). The enantioselective process is catalyzed by 1, which contains both Lewis base and Brønsted acid moieties.

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