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Dr. Jacques-Alexis Funel and Dr. Stefan Abele Industrial Applications of the Diels–Alder Reaction Angewandte Chemie International Edition 52

Version of Record online: 27 FEB 2013 | DOI: 10.1002/anie.201201636

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Diels–Alder reactions on a kg scale: The Diels–Alder reaction counts as one of the most popular transformations for the efficient synthesis of complex molecules, but its application in the industrial synthesis of pharmacologically active ingredients and agrochemicals as well as flavors and fragrances is less known. This Review gives examples of large-scale applications (>1 kg) from a process research and development perspective.

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