E-mail a Wiley Online Library Link

Kiyoun Lee, Prof. Dr. Hyoungsu Kim and Prof. Dr. Jiyong Hong N-Heterocyclic Carbene Catalyzed Oxidative Macrolactonization: Total Synthesis of (+)-Dactylolide Angewandte Chemie International Edition 51

Version of Record online: 26 APR 2012 | DOI: 10.1002/anie.201201653

Thumbnail image of graphical abstract

Three key steps constitute the total synthesis of (+)-dactylolide: the 1,6-oxa conjugate addition reaction of a 2,4-dienal for the facile synthesis of the 2,6-cis-2-(4-oxo-2-butenyl)tetrahydropyran subunit, the umpolung alkylation reaction of a cyanohydrin, and the NHC-catalyzed oxidative macrolactonization reaction for the synthesis of the 20-membered macrocyle. NHC=N-heterocyclic carbene.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field