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Dr. Elodie N. Marinoni, Dr. Jaim S. de Oliveira, Dr. Yvain Nicolet, Dr. Estella C. Raulfs, Dr. Patricia Amara, Prof. Dr. Dennis R. Dean and Dr. Juan C. Fontecilla-Camps (IscS-IscU)2 Complex Structures Provide Insights into Fe2S2 Biogenesis and Transfer Angewandte Chemie International Edition 51

Version of Record online: 18 APR 2012 | DOI: 10.1002/anie.201201708

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The center of attention: IscS cysteine desulfurases and IscU scaffolds are involved in biological iron–sulfur cluster assembly. The X-ray structure of an anaerobically produced, mutated (Fe2S2-(IscS-IscUD35A))2 complex reveals a cluster coordinated by three IscU cysteines and the IscS active cysteine (see picture). In air-exposed crystals the cluster is oxidized to an Fe2S–S center; D35 is essential for complex dissociation.

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