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Shiyue Duan, Weien Yuan, Fei Wu and Tuo Jin Polyspermine Imidazole-4,5-imine, a Chemically Dynamic and Biologically Responsive Carrier System for Intracellular Delivery of siRNA Angewandte Chemie International Edition 51

Version of Record online: 16 JUL 2012 | DOI: 10.1002/anie.201201793

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Silence please! Polyspermine imidazole-4,5-imine (blue lines) was formed by condensing spermine with bisformaldehyde imidazole through a pH-responsive linkage. This polymer was used to condense siRNAs into nanoparticles (see scheme) and studied for delivery into cells and release from endosomes. Cellular and in vivo assays indicated that this siRNA carrier was efficient in silencing target genes with negligible cytotoxicity.

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