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Joanna M. Krysiak, Johannes Kreuzer, Prof. Dr. Peter Macheroux, Prof. Dr. Albin Hermetter, Prof. Dr. Stephan A. Sieber and Prof. Dr. Rolf Breinbauer Activity-Based Probes for Studying the Activity of Flavin-Dependent Oxidases and for the Protein Target Profiling of Monoamine Oxidase Inhibitors Angewandte Chemie International Edition 51

Version of Record online: 11 JUN 2012 | DOI: 10.1002/anie.201201955

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High profile: New activity-based protein profiling (ABPP) probes have been designed that target exclusively monoamine oxidases A and B within living cells (see picture; FAD=flavin adenine dinucleotide, FMN=flavin monodinucleotide). With these probes it could be shown that the MAO inhibitor deprenyl, which is in clinical use against Parkinson's disease, shows unique protein specificity despite its covalent mechanism of action.

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