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Kyle D. Miner, Dr. Arnab Mukherjee, Yi-Gui Gao, Eric L. Null, Igor D. Petrik, Dr. Xuan Zhao, Dr. Natasha Yeung, Dr. Howard Robinson and Prof.Dr. Yi Lu A Designed Functional Metalloenzyme that Reduces O2 to H2O with Over One Thousand Turnovers Angewandte Chemie International Edition 51

Article first published online: 26 APR 2012 | DOI: 10.1002/anie.201201981

Thumbnail image of graphical abstract

No spare Tyr: Rational design of functional enzymes with a high number of turnovers is a challenge, especially those with a complex active site, such as respiratory oxidases. Introducing two His and one Tyr residues into myoglobin resulted in enzymes that reduce O2 to H2O with more than 1000 turnovers (red line, see scheme) and minimal release of reactive oxygen species. The positioning of the Tyr residue is critical for activity.

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