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Dr. Vijaya R. Pattabiraman, Ayodele O. Ogunkoya and Prof. Dr. Jeffrey W. Bode Cover Picture: Chemical Protein Synthesis by Chemoselective α-Ketoacid–Hydroxylamine (KAHA) Ligations with 5-Oxaproline (Angew. Chem. Int. Ed. 21/2012) Angewandte Chemie International Edition 51

Article first published online: 30 MAR 2012 | DOI: 10.1002/anie.201202064

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Chemoselective ligations of two unprotected protein segments that give a native amide bond are valued reactions for the synthesis of proteins. In their Communication on page 5114 ff., J. W. Bode et al. show that the α-ketoacid—hydroxylamine (KAHA) ligation with 5-oxaproline is an efficient reaction for the synthesis of proteins with unprotected protein segments in aqueous buffers. Prokaryotic ubiquitin-like protein and probable cold shock protein A have been synthesized.

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