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Dr. Birgit Habenstein, Dr. Luc Bousset, Yannick Sourigues, Dr. Mehdi Kabani, Dr. Antoine Loquet, Prof. Dr. Beat H. Meier, Dr. Ronald Melki and Dr. Anja Böckmann A Native-Like Conformation for the C-Terminal Domain of the Prion Ure2p within its Fibrillar Form Angewandte Chemie International Edition 51

Version of Record online: 3 JUL 2012 | DOI: 10.1002/anie.201202093

Thumbnail image of graphical abstract

Taking a definite stance: Protein fibrils are often associated with disorder and polymorphism, but the prion fibrils of Ure2p are shown (through solid-state NMR spectroscopy) to be highly ordered, and the conformations of the globular domain to be more restricted within the fibrils (black; see scheme) than in Ure2p single crystals (red). This finding implies that steric impairment is at the origin of the [URE3] phenotype in yeast.

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