Dr. Frederik Diness and Prof. David P. Fairlie Catalyst-Free N-Arylation Using Unactivated Fluorobenzenes Angewandte Chemie International Edition 51
Caught in a ‘SNAr'e: A one-step, high-yielding, catalyst-free method is described for N-arylation of azoles and indoles from unactivated monofluorobenzenes. This SNAr reaction tolerates a wide range of substituents and can also generate halogenated N-aryl products. The reaction can also be performed simultaneously with or subsequent to a copper- or palladium-catalyzed cross-coupling reaction in the same pot.
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