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Dr. Frederik Diness and Prof. David P. Fairlie Catalyst-Free N-Arylation Using Unactivated Fluorobenzenes Angewandte Chemie International Edition 51

Article first published online: 2 JUL 2012 | DOI: 10.1002/anie.201202149

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Caught in a ‘SNAr'e: A one-step, high-yielding, catalyst-free method is described for N-arylation of azoles and indoles from unactivated monofluorobenzenes. This SNAr reaction tolerates a wide range of substituents and can also generate halogenated N-aryl products. The reaction can also be performed simultaneously with or subsequent to a copper- or palladium-catalyzed cross-coupling reaction in the same pot.

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