Dr. Susanna Kushnir, Dipl.-Ing. (FH) Uschi Sundermann, Dr. Samir Yahiaoui, Dipl.-Ing. (FH) Andreas Brockmeyer, Dr. Petra Janning and Prof. Dr. Frank Schulz Minimally Invasive Mutagenesis Gives Rise to a Biosynthetic Polyketide Library Angewandte Chemie International Edition 51
Not in the public domain: Site-directed mutagenesis of megasynthases was the key to the generation of a library of polyketides in bacteria. Redox derivatizations are used to change the bioactivity profile of the compounds.
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