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Hong Liu, Dr. Yu Xiang, Prof. Yi Lu and Prof. Richard M. Crooks Aptamer-Based Origami Paper Analytical Device for Electrochemical Detection of Adenosine Angewandte Chemie International Edition 51

Version of Record online: 25 MAY 2012 | DOI: 10.1002/anie.201202929

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Paper biosensors: An origami sensor is printed on a single piece of paper, folded into a three-dimensional fluidic device, and encapsulated by thermal lamination. Aptamer is trapped in the fluidic channel, where it binds to the target and releases an enzyme to generate a signal. The device is read out using a digital multimeter.

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