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Dr. Kevin Pagel, Dr. Eviatar Natan, Zoe Hall, Prof. Dr. Alan R. Fersht and Prof. Dr. Carol V. Robinson Intrinsically Disordered p53 and Its Complexes Populate Compact Conformations in the Gas Phase Angewandte Chemie International Edition 52

Article first published online: 9 JUL 2012 | DOI: 10.1002/anie.201203047

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Spontaneous shrinking: The intrinsically disordered tumor suppressor protein p53 was analyzed by using a combination of ion mobility mass spectrometry and molecular dynamics simulations. Structured p53 subdomains retain their overall topology upon transfer into the gas phase. When intrinsically disordered segments are introduced into the protein sequence, however, the complex spontaneously collapses in the gas phase to a compact conformation.

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