Jiajing Tan, Dr. Cheol-Hong Cheon and Prof. Hisashi Yamamoto Catalytic Asymmetric Claisen Rearrangement of Enolphosphonates: Construction of Vicinal Tertiary and All-Carbon Quaternary Centers Angewandte Chemie International Edition 51
A copper-catalyzed enantioselective Claisen rearrangement of easily accessible enolphosphonates using the commercially available PhBOX as the chiral ligand was developed. A wide range of rearrangement products with contiguous tertiary and all-carbon quaternary centers were obtained in excellent yields and stereoselectivities. The α-ketophosphonate substituent in the products could be easily transformed into other functional groups.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf