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Ido M. Herzog, Dr. Keith D. Green, Yifat Berkov-Zrihen, Dr. Mark Feldman, Dr. Roee R. Vidavski, Anat Eldar-Boock, Dr. Ronit Satchi-Fainaro, Dr. Avigdor Eldar, Dr. Sylvie Garneau-Tsodikova and Dr. Micha Fridman Inside Cover: 6′′-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes (Angew. Chem. Int. Ed. 23/2012) Angewandte Chemie International Edition 51

Version of Record online: 13 MAY 2012 | DOI: 10.1002/anie.201203240

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Amphiphilic aminoglycoside antibiotics kill bacteria by disruption of their highly negatively charged membrane. In their Communication on page 5652 ff., M. Fridman, S. Garneau-Tsodikova, and co-workers report the synthesis of 6′′-thioether tobramycin derivatives and show that their aliphatic chain acts as a drill bit that can rupture bacterial cells. These potent compounds evade many of the common bacterial resistance mechanisms, thereby opening a new avenue for the discovery of membrane-targeting antibiotics.

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